The relationship between race and HIV-distal sensory polyneuropathy in a large cohort of US women

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• 作者：Yaacov Anziska^a ; ^{yanziska@downstate.edu} ; Elizabeth P. Helzner^b ; Howard Crystal^a ; Marshall J. Glesby^c ; Michael Plankey^d ; Kathleen Weber^e ; Elizabeth Golub^f ; Pamela Burian^g
• 关键词：HIV-associated sensory polyneuropathy ; African-Americans ; Race ; Women ; Gender ; Diabetes ; Hepatitis C
• 刊名：Journal of the Neurological Sciences
• 出版年：2012
• 期刊代码：178_0022510x
• 类别：med
• 出版时间：15 April, 2012
• 卷：315
• 期：1-2
• 页码：129-132
• 文件大小：156 K

摘要

Introduction

HIV-distal sensory polyneuropathy (HIV-DSPN) is a common complication of HIV infection, yet race as a potential risk factor is not known.

Methods

Between April and October 2009, as part of the NIH Women's Interagency HIV Study (WIHS), 1414 women, 973 of whom were HIV-infected, were clinically evaluated for peripheral neuropathy. Utilizing available clinical, laboratory, and sociodemographic variables, we conducted a cross-sectional analysis of factors associated with HIV-DSPN. Multivariable logistic regression was used to examine factors independently associated with HIV-DSPN.

Results

36%of HIV-infected women met our definition of HIV-DSPN. 41.3%of African Americans, 34.8%of Whites and 24.7%of Hispanics had DSPN. Age, Hepatitis C-co-infection, and diabetes were each significantly associated with HIV-DSPN. After controlling for age, diabetes, Hepatitis C co-infection, alcohol use, current dideoxy-nucleoside reverse transcriptase inhibitor use, current CD4 count, and plasma HIV viral load, HIV-DSPN was significantly associated with ethnicity; the odds ratio was 1.67 (p = 0.001) in African-Americans compared to other racial groups.

Conclusion

The prevalence of HIV-DSPN in women was lower than reported in prior studies. The likelihood of HIV-DSPN was higher in African-Americans compared to other racial groups. HIV-DSPN was more common in those co-infected with Hepatitis C, older individuals, and diabetics. Further prospective studies are needed to explore the relationship between gender, race, and HIV-DSPN, and the mechanistic basis for racial differences.