• 作者：Pilar Guallar-Castilló ; n^a ; ^b ; ^{mpilar.guallar@uam.es} ; Miriam Gil-Montero^a ; ^c ; Luz M. Leó ; n-Muñ ; oz^a ; ^b ; Auxiliadora Graciani^a ; ^b ; Ana Bay&#225 ; n-Bravo^a ; José ; M. Taboada^d ; José ; R. Banegas^a ; ^b ; Fernando Rodrí ; guez-Artalejo^a ; ^b
• 关键词：cHDL ; colesterol unido a lipoproteí ; nas de alta densidad ; cLDL ; colesterol unido a lipoproteí ; nas de baja densidad ; CT ; colesterol sé ; rico total ; ECV ; enfermedad cardiovascular ; IMC ; í ; ndice de masa corporal ; TGC ; triglicé ; ri
• 刊名：Revista Espa?ola de Cardiolog篓陋a
• 出版年：2012
• 期刊代码：pca308_03008932
• 类别：med
• 出版时间：June, 2012
• 卷：65
• 期：6
• 页码：551-558
• 文件大小：429 K

Introduction and objectives

Only a few studies have reported nationwide population-based data on the magnitude and control of hypercholesterolemia. This work examines the prevalence and management of hypercholesterolemia in Spain.

Methods

Cross-sectional study conducted from June 2008 to October 2010 on 11聽554 individuals representative of the population aged 鈮?8 years in Spain. Study participants provided 12-h fasting blood samples, which were analyzed in a central laboratory with standardized methods.

Results

In the whole population, 50.5%had hypercholesterolemia (total cholesterol 鈮?00 mg/dL or drug treatment) and 44.9%high levels of low-density lipoprotein cholesterol (鈮?30 mg/dL or drug treatment), with no substantial sex-related differences. Moreover, 25.5%of men showed high-density lipoprotein cholesterol <40 mg/dL and 26.4%of women high-density lipoprotein cholesterol <50 mg/dL. Also, 23.2%of men and 11.7%of women had triglycerides 鈮?50 mg/dL. Frequency of dyslipidemia increased up to 65 years, except for low high-density lipoprotein cholesterol which did not vary with age. Among those with high low-density lipoprotein cholesterol, 53.6%knew of it and 44.1%of them received lipid-lowering treatment; among the latter, 55.7%had a controlled level (13.2%of all hypercholesterolemics). Control of high low-density lipoprotein cholesterol increased with age and with the number of visits to the specialist physician, but was lower among diabetics (odds ratio=0.38; 95%confidence interval, 0.28-0.53) and patients with cardiovascular disease (odds ratio=0.55; 95%confidence interval, 0.33-0.92).

Conclusions

About half of the Spanish population has elevated serum cholesterol; moreover, cholesterol control is poor, particularly among those with highest cardiovascular risk, such as diabetics or patients with cardiovascular disease.

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