Cardiac autonomic modulation during methadone therapy among heroin users: A pilot study

详细信息	查看全文 | 推荐本文 |

• 作者：Li-Ren Chang^a ; ¹ ; Yu-Hsuan Lin^a ; ^b ; ¹ ; Terry B.J. Kuo^b ; ^c ; Yen-Cheng Ho^d ; Shiuan-Horng Chen^e ; Hung-Chieh Wu Chang^a ; Chih-Min Liu^a ; Cheryl C.H. Yang^b ; ^c ; ^{cchyang@ym.edu.tw}
• 关键词：ANOVA ; One-Way Analysis of Variance ; ANS ; Autonomic Nervous System ; DSM-IV-TR ; Diagnostic and Statistical Manual of Mental Disorders ; 4th ed. ; Text Revision ; ECG ; Electrocardiogram ; HF ; High-Frequency Power ; HRV ; Heart Rate Variability ; LF ; Low-Frequency
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2012
• 期刊代码：222_02785846
• 类别：med
• 出版时间：27 April, 2012
• 卷：37
• 期：1
• 页码：188-193
• 文件大小：207 K

摘要

Background

Methadone therapy benefits heroin users in both the medical and psychosocial dimensions. However, both heroin and methadone have cardiac toxicity. Only limited information is available describing the changes in cardiac autonomic function of heroin users and effects of methadone therapy. We conduct the current study to explore the cardiac vagal function in heroin users as well as the impact of lapse and methadone therapy.

Methods

80 heroin users from a methadone therapy clinic were distributed into 31 compliant and 49 incompliant patients according to whether they lapsed into heroin use within 10 days. 40 healthy control subjects were recruited from the community. Participants underwent electrocardiographic recordings and the heroin users were further investigated before and after methadone therapy. Spectral analysis of heart rate variability (HRV) was computed for cardiac parasympathetic modulation (high-frequency power, HF) and cardiac sympathetic modulation (normalized low-frequency power, LF%).

Results

The baseline HRV parameters found lower HF values for heroin users and lower RR interval values for patients with a recent lapse compared with the healthy control subjects. After 1 h of methadone administration, heroin users who had lapsed showed a significant increase in HF but the heroin users who had not lapsed did not.

Conclusion

Our findings suggest that heroin users show decreased cardiac vagal activity and that methadone therapy immediately facilitates vagal regulation in patients with a recent lapse. The differential patterns of autonomic alteration under methadone between those with and without lapse might offer an objective measure of lapse.