African ancestry and lung function in Puerto Rican children

详细信息	查看全文 | 推荐本文 |

• 作者：John M. Brehm ; MD ; MPH^a ; Edna Acosta-Pé ; rez ; PhD^b ; Lambertus Klei ; PhD^c ; Kathryn Roeder ; PhD^d ; Michael M. Barmada ; PhD^e ; Nadia Boutaoui ; PhD^a ; Erick Forno ; MD ; MPH^f ; Michelle M. Cloutier ; MD^g ; Soma Datta ; MS^h ; Roxanne Kelly ; MBA^h ; Kathryn Paul ; BS^h ; Jody Sylvia ; MS^h ; Deanna Calvert ; BSⁱ ; Sherell Thornton-Thompson ; CCRPⁱ ; Dorothy Wakefield ; MS^g ; Augusto A. Litonjua ; MD ; MPH^h ; Marí ; a Alvarez ; MD^b ; Angel Coló ; n-Semidey ; MD^b ; Glorisa Canino ; PhD^b ; Juan C. Celedó ; n ; MD ; DrPH^a ; ^{juan.celedon@chp.edu}
• 关键词：Ancestry ; FEV1 ; forced vital capacity ; Puerto Ricans ; childhood
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2012
• 期刊代码：158_00916749
• 类别：med
• 出版时间：June, 2012
• 卷：129
• 期：6
• 页码：1484-1490.e6
• 文件大小：229 K

摘要

| Figures/TablesFigures/Tables | ReferencesReferences

Background

Puerto Rican and African American subjects share a significant proportion of African ancestry. Recent findings suggest that African ancestry influences lung function in African American adults.

Objective

We sought to examine whether a greater proportion of African ancestry is associated with lower FEV₁ and forced vital capacity (FVC) in Puerto Rican children independently of socioeconomic status, health care access, or key environmental/lifestyle factors.

Methods

We performed a cross-sectional case-control study of 943 Puerto Rican children aged 6 to 14 years with (n聽= 520) and without (n聽= 423) asthma (defined as physician-diagnosed asthma and wheeze in the prior year) living in Hartford, Connecticut (n聽= 383), and San Juan, Puerto Rico (n聽= 560). We estimated the percentage of African racial ancestry in study participants using genome-wide genotypic data. We tested whether African ancestry is associated with FEV₁ and FVC using linear regression. Multivariate models were adjusted for indicators of socioeconomic status and health care and selected environmental/lifestyle exposures.

Results

After adjustment for household income and other covariates, each 20%increment in African ancestry was significantly associated with lower prebronchodilator FEV₁ (鈭?05 mL; 95%CI, 鈭?59 to 鈭?1 mL; P聽< .001) and FVC (鈭?33 mL; 95%CI, 鈭?97 to 鈭?9 mL; P聽< .001) and postbronchodilator FEV₁ (鈭?52 mL; 95%CI, 鈭?10 to 鈭?4 mL; P聽< .001) and FVC (鈭?45 mL; 95%CI, 鈭?11 to 鈭?9 mL; P聽< .001) in children with asthma. Similar but weaker associations were found for prebronchodilator and postbronchodilator FEV₁ (change for each 20%increment in African ancestry, 鈭?8 mL; 95%CI, 鈭?31 to 鈭?5 mL; P聽= .004) and for postbronchodilator FVC among children without asthma.

Conclusions

Genetic factors, environmental/lifestyle factors, or both correlated with African ancestry might influence childhood lung function in Puerto Rican subjects.