Asymmetric hydrogenation of imines catalyzed by iridium complexes with phosphine脙脙脙脙脙脙phosphite ligands: importance of backbone flexibility
- 作者：Vargas ; Sergio ; Rubio ; Miguel ; Su脙脙rez ; Andr脙脙s ; Pizzano ; Antonio
- 关键词：Asymmetric hydrogenation ; Chiral amines ; Phosphine脙脙脙脙脙脙phosphites
- 刊名：Tetrahedron Letters
- 出版年：2005
- 期刊代码：109_00404039
- 类别：ch
- 出版时间：March 21, 2005
- 卷：46
- 期：12
- 页码：2049-2052
- 文件大小：114 K
摘要
Chiral phosphine芒芒芒phosphites provide an alternative class of ligands for the iridium catalyzed enantioselective hydrogenation of imines. Optimization of ligand structure has afforded enantioselectivities up to 84%ee in the reduction of N-aryl imines. A significant influence of backbone nature on enantioselectivity has also been observed.