Scandium triflate as an efficient and useful catalyst for the synthesis of β-amino alcohols by regioselective ring opening of epoxides with amines under solvent-free conditions

详细信息	查看全文 | 推荐本文 |

• 作者：Andrew T. Placzek ; James L. Donelson ; Rushi Trivedi ; Richard A. Gibbs and Surya K. De
• 刊名：Tetrahedron Letters
• 出版年：2005
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：26 December 2005
• 卷：46
• 期：52
• 页码：9029-9034
• 文件大小：126 K

摘要

A simple and efficient method has been developed for the synthesis of β-amino alcohols by ring opening of epoxides in the presence of a catalytic amount of Sc(OTf)₃ at room temperature under solvent-free conditions. The reaction works well with both aromatic and aliphatic amines. High regio-, and diastereoselectivity can be considered as a noteworthy advantage of this method.