Anti-oxidative properties of beta-blockers and angiotensin-converting enzyme inhibitors in congestive heart failure
- 作者：Chin ; Bernard S.P. ; Langford ; Nigel J. ; Nuttall ; Sarah L. ; Gibbs ; Christopher R. ; Blann ; Andrew D. ; et. al.
- 关键词：Beta-blockers ; Congestive heart failure ; ACE inhibitors ; Oxidative stress ; Endothelial damage/dysfunction
- 刊名：European Journal of Heart Failure
- 出版年：2003
- 期刊代码：90_13889842
- 类别：med
- 出版时间：March, 2003
- 卷：5
- 期：2
- 页码：171-174
- 文件大小：71.8 K
摘要
Background: Chronic elevation of plasma catecholamines and sympathetic stimulation in chronic heart failure (CHF) leads to increased production of free radicals, and so possibly to endothelial damage/dysfunction and atheroma formation. Abnormal oxidative stress may therefore be related to some of the high mortality and morbidity in CHF. The objective of the present prospective open study was to compare the effects of β-blockers and ACE inhibitors in relation to oxidative stress and endothelial damage in CHF. Methods: We studied 66 outpatients with CHF: 46 patients were established on an ACE inhibitor and were then started on a β-blocker, and 20 patients not previously on ACE-inhibitors were started on lisinopril. Baseline levels of the measured parameters were compared to 22 healthy control subjects. Serum lipid hydroperoxides (LHP) and total antioxidant capacity (TAC) were determined as indices of oxidative damage and antioxidant defence, and plasma von Willebrand factor (vWf) as an index of endothelial damage/dysfunction. Results: Baseline indices for the measures of oxidative damage and endothelial function in the 66 CHF patients were significantly higher than healthy control subjects [median LHP 7.5 (5.9–12.6) vs. 4.8 μmol/l, P