Preservation of cortical histamine H<sub>3sub> receptors in ischemic vascular and mixed dementias
- 作者：Yuan Sheng<sup>asup><sup> ; sup><sup>bsup> ; Jasinda H. Lee<sup>asup><sup> ; sup><sup>bsup> ; Andrew D. Medhurst<sup>csup><sup> ; sup><sup>1sup> ; Gordon K. Wilcock<sup>dsup> ; Margaret Esiri<sup>dsup> ; Peter T.-H. Wong<sup>asup><sup> ; sup><sup>bsup> ; Christopher P. Chen<sup>asup><sup> ; sup><sup>bsup> ; Mitchell K.P. Lai<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>mitchell.lai@dementia-research.orgsup>
- 关键词：Alzheimer's disease ; Histamine H3 receptors ; Mixed dementia ; Subcortical ischemic vascular dementia ; Neocortex ; Hippocampus
- 刊名：Journal of the Neurological Sciences
- 出版年：2012
- 期刊代码：178_0022510x
- 类别：med
- 出版时间：15 April, 2012
- 卷：315
- 期：1-2
- 页码：110-114
- 文件大小：294 K
摘要
ss="h4">Aim
Histamine H<sub>3sub> receptor antagonists have been proposed as a novel therapeutic approach for the symptomatic treatment of Alzheimer's disease (AD). However, it is unclear whether there is a neurochemical basis for extending their potential use in vascular and mixed dementias. In this study, we measured cortical H<sub>3sub> receptors in patients with subcortical ischemic vascular dementia (SIVD) and mixed SIVD/AD (MIX).ss="h4">Materials and methods
Radioligand binding assays using [<sup>3sup>H]GSK189254 were used to measure H<sub>3sub> receptors in the postmortem frontal cortex, anterior cingulate gyrus and hippocampus of a cohort of longitudinally assessed SIVD, MIX and age-matched controls.
ss="h4">Results
H<sub>3sub> receptor levels were unchanged in SIVD and MIX in all areas studied. Furthermore, frontal H<sub>3sub> receptor densities negatively correlated with predeath assessment of cognition using Mini-Mental State Examination (MMSE) scores.
ss="h4">Conclusion
Our data suggest that H<sub>3sub> receptors are preserved in SIVD and MIX, thus supporting further assessments of H<sub>3sub> antagonists as potential therapeutics in these dementias.