Magnetization transfer and adiabatic R<sub>1蟻sub> MRI in the brainstem of Parkinson鈥檚 disease

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• 作者：Paul J. Tuite<sup>bsup><sup> ; sup><sup>tuite002@umn.edusup> ; Silvia Mangia<sup>asup> ; Andrew E. Tyan<sup>asup> ; Michael K. Lee<sup>csup> ; Michael Garwood<sup>asup> ; Shalom Michaeli<sup>asup>
• 关键词：Parkinson&rsquo ; s disease ; Medulla ; MRI ; Magnetization transfer ; R1蟻
• 刊名：Parkinsonism and Related Disorders
• 出版年：2012
• 期刊代码：215_13538020
• 类别：med
• 出版时间：June, 2012
• 卷：18
• 期：5
• 页码：623-625
• 文件大小：393 K

摘要

ss="h4">Background

In addition to classic midbrain pathology, Parkinson鈥檚 disease (PD) is accompanied by changes in pontine and medullary brainstem structures. These additional abnormalities may underlie non-motor features as well as play a role in motor disability. Methods: Using novel magnetic resonance imaging (MRI) methods based on rotating frame adiabatic R<sub>1蟻sub> (i.e., measurements of longitudinal relaxation during adiabatic full passage pulses) and modified magnetization transfer (MT) MRI mapping, we sought to identify brainstem alterations in nine individuals with mild-moderate PD (off medication) and ten age-matched controls at 4聽T. Results: We discovered significant differences in MRI parameters between midbrain and medullary brainstem structures in control subjects as compared to PD patients. Conclusions: These findings support the presence of underlying functional/structural brainstem changes in mild-moderate PD.