摘要
Two series of fused tricyclic indoles were identified as potent and selective S1P<sub>1sub> agonists. In vivo these agonists produced a significant reduction in circulating lymphocytes which translated into robust efficacy in several rodent models of autoimmune disease. Importantly, these agonists were devoid of any activity at the S1P<sub>3sub> receptor in vitro, and correspondingly did not produce S1P<sub>3sub> mediated bradycardia in telemeterized rat.