Determination of 17 macrolide antibiotics and avermectins residues in meat with accelerated solvent extraction by liquid chromatography-tandem mass spectrometry

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• 作者：Yanfei Tao^a ; Gang Yu^a ; ^b ; Dongmei Chen^a ; Yuanhu Pan^a ; Zhenli Liu^a ; Huimin Wei^a ; Dapeng Peng^a ; Lingli Huang^a ; Yulian Wang^a ; Zonghui Yuan^a ; ^{yuanzh58@hotmail.com} ; ^{yuan5802@mail.hzau.edu.cn}
• 关键词：Macrolide antibiotics ; Avermectins ; ASE ; Animal origin food ; LC&ndash ; MS/MS
• 刊名：Journal of Chromatography B ; Analytical Technologies in the Biomedical and Life Sciences
• 出版年：2012
• 期刊代码：124_15700232
• 类别：ch
• 出版时间：15 May, 2012
• 卷：897
• 期：Complete
• 页码：64-71
• 文件大小：579 K

摘要

A method has been developed for simultaneous determination of 17 kinds of macrolide antibiotics and avermectins residues in animal origin foods. Samples were extracted with acetonitrile-methanol using accelerated solvent extraction (ASE) instrument. Parameters such as extraction temperature and pressure were investigated by a fractional factorial design (FFD) and the selected extraction (60 掳C, 1500 psi for 10 min in two cycles) was most effective. High correlation coefficients (r > 0.999) of 17 macrolide antibiotics and avermectins were obtained within their respective linear ranges (2-400 渭g/kg) using roxithromycin as internal standard. The recoveries of them were above 75%at different spiked levels in various samples. Using ASE the method was featured as short extraction times, reduction use of extraction solvent, high extraction yields, with high level of automation.