Body mass index is associated with biological CSF markers of core brain pathology of Alzheimer's disease

详细信息	查看全文 | 推荐本文 |

• 作者：Michael Ewers^a ; ^b ; ^{michael.ewers@va.gov} ; Susanne Schmitz^c ; Oskar Hansson^d ; Cathal Walsh^c ; Annette Fitzpatrick^e ; David Bennett^f ; Lennart Minthon^d ; John Q. Trojanowski^g ; Leslie M. Shaw^g ; Yetunde O. Faluyi^h ; Bruno Vellasⁱ ; Bruno Dubois^j ; Kaj Blennow^k ; Katharina Buerger^l ; Stefan J. Teipel^m ; ⁿ ; Michael Weiner^a ; ^b ; Harald Hampel^o ; Alzheimer's Disease Neuroimaging Initiative
• 关键词：Alzheimer's disease ; Body mass index ; Cerebrospinal fluid ; Tau protein ; A尾1&ndash ; 42
• 刊名：Neurobiology of Aging
• 出版年：2012
• 期刊代码：202_01974580
• 类别：med
• 出版时间：August, 2012
• 卷：33
• 期：8
• 页码：1599-1608
• 文件大小：1269 K

摘要

Weight changes are common in aging and Alzheimer's disease (AD) and postmortem findings suggest a relation between lower body mass index (BMI) and increased AD brain pathology. In the current multicenter study, we tested whether lower BMI is associated with higher core AD brain pathology as assessed by cerebrospinal fluid (CSF)-based biological markers of AD in 751 living subjects: 308 patients with AD, 296 subjects with amnestic mild cognitive impairment (MCI), and 147 elderly healthy controls (HC). Based upon a priori cutoff values on CSF concentration of total tau and beta-amyloid (A尾_1-42), subjects were binarized into a group with abnormal CSF biomarker signature (CSF+) and those without (CSF鈭?. Results showed that BMI was significantly lower in the CSF+ when compared with the CSF鈭?group (F = 27.7, df = 746, p < 0.001). There was no interaction between CSF signature and diagnosis or apolipoprotein E (ApoE) genotype. In conclusion, lower BMI is indicative of AD pathology as assessed with CSF-based biomarkers in demented and nondemented elderly subjects.