Pelvic exenteration for primary and recurrent gynaecological malignancies

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• 作者：Johannes H.W. de Wilt ; Diederik H.-J. van Leeuwen ; Adriaan Logmans ; Cornelis Verhoef ; Wim J. Kirkels ; Maarten Vermaas ; Anca C. Ansink
• 关键词：Pelvic ; Exenteration ; Gynaecology ; Surgery ; Cancer
• 刊名：European Journal of Obstetrics and Gynecology and Reproductive Biology
• 出版年：2007
• 期刊代码：92_03012115
• 类别：med
• 出版时间：October 2007
• 卷：134
• 期：2
• 页码：243-248
• 文件大小：190 K

摘要

Analyse the outcome of pelvic exenteration for gynaecological malignancies in a tertiary referral center. Post-operative in-hospital morbidity, long-term morbidity, disease free and overall survival rates were studied.

Study design

Between 1991 and 2004, 42 patients underwent an anterior, total or posterior exenteration for gynaecological malignancies. Follow-up was obtained from patient files; disease free and overall survival were calculated and prognostic factors were studied.

Results

A pelvic exenteration was performed in 14 patients for primary and 28 patients for recurrent gynaecological cancers. In-hospital complications occurred in 19 patients (45%) of whom seven patients needed a reoperation (17%). Late complications occurred in 31 patients (75%); 21 reinterventions were performed (50%). Five-year disease free and overall survival was, respectively, 48 and 52%. Age, type of surgery, histology, localisation of the tumour, lateral wall involvement, completeness of resection and primary versus recurrent cancer were not identified as prognostic factors for recurrence or survival.

Conclusion

Long-term survival is possible in about 50%of patients after pelvic exenteration for gynaecological cancers, but is associated with significant post-operative morbidity.