The 5HT2 receptor as a site for antipsychotics
- 作者：Kerwin ; Robert
- 刊名：European Psychiatry
- 出版年：1996
- 期刊代码：96_09249338
- 类别：med
- 出版时间：1996
- 卷：11
- 期：4, Supplement
- 页码：227s
- 文件大小：116 K
摘要
The advent of newer antipsychotics such as clozapine and risperidone which have greater affinity for 5HT2 receptors has awakened interest in this site as a therapeutic target in schizophrenia. Studies on 5HT2 receptors post-mortem have consistently shown elevations in schizophrenia and selective 5HT2 receptor antagonists have properties overlapping atypical drugs which include a weak effect on negative symptoms and few extrapyramidal consequences. We have been testing whether the 5HT2 receptor mediates antipsychotic effect by correlating variation in clinical response to clozapine with polymorphic variation in polymorphisms for 5HT2a and 5HT2c receptors. So far we have studied a silent T to C change at position 106 of the 5HT2a receptor and a cystine to serine polymorphism at position 68 of the 5HT2c receptor. When analysed according to allotype or genotype in 174 patients the possession of a C allele in the 5HT2a receptors is more significantly associated with non response and possession of a serine allele in the 5HT2c is significantly associated with response. In addition a low frequency histidine to tyrosine variant close to the C terminus of 5HT2a is exclusively associated with non response. Although the mechanisms of these effects are not understood, taken together these results confirm the 5HT2 system as a mediator of antipsychotic effect and suggests that improving selectivity and affinity of drugs for these sites is a worthwhile strategy for drug discovery.