Polymorphisms in cytotoxic T lymphocyte associated antigen-4 influence the rate of acute rejection after renal transplantation in 167 Chinese recipients

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• 作者：Jun-wei Gao^a ; Yi-feng Guo^b ; ^{gyfmd1@gmail.com} ; Yu Fan^b ; Jian-xin Qiu^b ; Er-dun Bao^b ; Yong Liu^b ; Yan Qin^b ; Fang Zhang^b
• 关键词：Cytotoxic T lymphocyte associated antigen 4 (CTLA4) ; Single nucleotide polymorphisms (SNP) ; Renal transplantation ; Acute rejection
• 刊名：Transplant Immunology
• 出版年：2012
• 期刊代码：251_09663274
• 类别：med
• 出版时间：June, 2012
• 卷：26
• 期：4
• 页码：207-211
• 文件大小：155 K

摘要

Gene polymorphisms of cytotoxic T lymphocyte associated antigen 4 (CTLA4) play an influential role in the graft rejection and long-term clinical outcome of organ transplantation. We investigated the associations of five CTLA4 single nucleotide polymorphisms (SNPs) (rs733618T/C, rs4553808A/G, rs5742909C/T, rs231775G/A, rs3087243G/A) on the early acute rejection (AR) of Chinese deceased donor renal transplantation recipients. Genotyping of the CTLA4 SNPs was performed in 167 deceased donor renal transplantation recipients. Each patient underwent a 6-month follow-up observation for AR. The incidence of AR during the 6 months post-transplantation was 26.9%(45 out of 167 patients). Patients experiencing AR were found to have a higher frequency of the rs733618TT genotype and T allele (p = 0.000 and p = 0.002, respectively). While the haplotype CACAG was merely observed in non-AR group (corrected p = 0.000), the frequency of haplotype TACGG was significantly higher in AR group than in non-AR group even after 50,000 permutation tests (corrected p = 0.018). In conclusion, these polymorphisms statistically significantly associated with acute renal allograft rejection may be considered as a risk factor of AR in Chinese renal transplantation recipients except for haplotype CACAG as a protective one.