β-Lactam antibiotics, β-lactamases and bacterial resistance
- 作者：Kotra ; L.P. ; Mobashery ; S.
- 关键词：β ; -Lactam ; Antibiotic ; β ; -Lactamase ; Resistance ; Review ; β ; -Lactame ; β ; -Lactamase ; Antibioré ; sistance ; Revue
- 刊名：Bulletin de l'Institut Pasteur
- 出版年：1998
- 期刊代码：15_00202452
- 类别：imm
- 出版时间：July 9, 1998
- 卷：96
- 期：3
- 页码：139-150
- 文件大小：947 K
摘要
β-Lactams are the most prescribed antibacterials for the treatment of bacterial infections. Bacteria have developed mechanisms to resist the action of β-lactam drugs, of which the catalytic function of β-lactamase is the most important. These enzymes catalyse hydrolysis of β-lactam antibiotics, whereby the drug is destroyed. This review offers a perspective on the function of these enzymes and their clinical implications.