Synthesis, structure, DNA-binding properties and cytotoxic activities of a new one-dimensional polymeric copper(II) complex with N-benzoate-N鈥?[3-(2-hydroxyl-ethylammino)propyl]oxamide as ligand

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• 作者：Xin Li^a ; Yan-Tuan Li^a ; ^{yantuanli@ouc.edu.cn} ; Zhi-Yong Wu^b ; Yong-Jun Zheng^b ; Cui-Wei Yan^c ; ^{cuiweiyan@ouc.edu.cn}
• 关键词：Polymeric copper(II) complex ; Crystal structure ; Oxamido-bridge ; Carboxylato-bridge ; DNA-binding properties ; Cytotoxic activities
• 刊名：Inorganica Chimica Acta
• 出版年：2012
• 期刊代码：40_00201693
• 类别：ch
• 出版时间：30 April, 2012
• 卷：385
• 期：Complete
• 页码：150-157
• 文件大小：741 K

摘要

A new one-dimensional polymeric copper(II) complex, [Cu₂(bhpox)(phen)]⁺_n路nClO₄^{鈭?/sup>路nH₂O, where bhpox3鈭?/sup> and phen stand for N-benzoate-N鈥?[3-(2-hydroxyethylammino)propyl]oxamide and 1,10-phenanthroline, respectively, has been synthesized and characterized by elemental analysis, molar conductivity measurement, IR and electronic spectra studies, and single-crystal X-ray diffraction. The complex crystallizes in monoclinic space group P2₁/c with crystallographic data: a = 13.8500(2) 脜, b = 13.3321(2) 脜, c = 15.8532(2) 脜, and Z = 4. In the crystal structure, the cation [Cu₂(bhpox)(phen)]_nn+ exhibits a one-dimensional zigzag-like structure for copper(II) ions alternately bridged by cis-oxamido and carboxylato groups, with the Cu鈰疌u separations of 5.1928(4) and 5.5240(5) 脜, respectively. Each copper(II) ion is located in a slightly distorted square-pyramidal environment. Hydrogen bonds and 蟺-蟺 stacking interactions contribute to a three-dimensional supramolecular structure in the crystal. The interactions between the copper(II) complex and herring sperm DNA (HS-DNA) have been investigated by using electronic absorption titration, fluorescence titration, electrochemical titration and viscometry. All the experiments reveal that the copper(II) complex interacts with HS-DNA in the mode of intercalation with the intrinsic binding constant K_b = 2.67 脳 104 M鈭?. The copper(II) complex exhibits potent anticancer activities against human hepatocellular carcinoma cell SMMC-7721 and human lung adenocarcinoma cell A549.}