Scaffold hybridization in generation of indenoindolones as anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase

详细信息	查看全文 | 推荐本文 |

• 作者：Maneesh Kashyap^a ; Dipon Das^b ; Ranjan Preet^b ; Purusottam Mohapatra^b ; Shakti Ranjan Satapathy^b ; Sumit Siddharth^c ; Chanakya N. Kundu^b ; ^{cnkundu@gmail.com} ; Sankar K. Guchhait^a ; ^{skguchhait@niper.ac.in}
• 关键词：Indenoindolones ; Hybrid ; Anticancer ; Cell cycle ; Apoptosis
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：1 April, 2012
• 卷：22
• 期：7
• 页码：2474-2479
• 文件大小：1026 K

摘要

Scaffold hybridization of several natural and synthetic anticancer leads led to the consideration of indenoindolones as potential novel anticancer agents. A series of these compounds were prepared by a diversity-feasible synthetic method. They were found to possess anticancer activities with higher potency compared to etoposide and 5-fluorouracil in kidney cancer cells (HEK 293) and low toxicity to corresponding normal cells (Vero). They exerted apoptotic effect with blocking of cell cycle at G2/M phase.