Anti-annexin A5 antibodies in women with spontaneous pregnancy loss

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• 作者：Jaume Alijotas-Reig^a ; ^{jalijotas@vhebron.net} ; Raquel Ferrer-Oliveras^b ; Marí ; a José ; Rodrigo-Anoro^c ; ^d ; Inmaculada Farran-Codina^b ; Elisa Llurba-Olivé ; ^b ; Miquel Vilardell-Tarres^a ; Manel Casellas-Caro^b ; ^e
• 关键词：Anti-annexin A5 antibodies ; Antiphospholipid antibodies ; Antiphospholipid syndrome ; Recurrent miscarriage ; Unexplained fetal losses
• 刊名：Medicina Cl铆nica
• 出版年：2010
• 期刊代码：pca254_00257753
• 类别：med
• 出版时间：10 April 2010
• 卷：134
• 期：10
• 页码：433-438
• 文件大小：162 K

摘要

Background and Objective

The aim was to evaluate the role of anti-annexin A5 (anti-ANXA5) antibodies as risk factor for recurrent miscarriage (RM) and unexplained fetal loss (UFL).

Patients and methods

Retrospective, cohort study. Setting: Vall d鈥橦ebron University Hospital. Subjects: 122 women, in two groups: Study group: 54 women with RM/UFL and control group: 68 pregnant without RM/UFL. Intervention: Antiphospholipid, mainly anti-ANXA5 antibody analysis. Comparison of all antiphospholipid antibodies between groups.

Results

Antiphospholipid antibody (aPL) prevalence in the study group was 10/54 (14.8%) and 5/68 (7.3%) in control group (p=0.09). In the RM subgroup, it was 3/25 and 9/34 in UFL versus 5/68 in controls (p=0.013). Lupus anticoagulant (LA) was present in 4 cases, all belonging to the study group (p=0.011). Four out of 34 women with UFL were positive for anticardiolipin antibodies-IgG (IgG-aCL) versus 1/68 in controls (p=0.041). In RM subgroup, anti-ANXA5 antibodies were positive in 2/25 versus 3/68 in controls, and in UFL subgroup, 3/34 versus 3/68 cases (p=1.000).

Conclusion

According to our results, anti-ANXA5 antibodies should not be considered as a risk factor for RM/UFL.