Chronic administration of atorvastatin induced anti-convulsant effects in mice: The role of nitric oxide

详细信息	查看全文 | 推荐本文 |

• 作者：Leila Moezi^a ; Hamed Shafaroodi^b ; ^{Shafaroodih@yahoo.com} ; Mahsa Hassanipour^b ; Ali Fakhrzad^a ; Sara Hassanpour^b ; Ahmad Reza Dehpour^c
• 关键词：Atorvastatin ; HMG-CoA reductase inhibitors ; Convulsion ; Seizure ; Nitric oxide ; Mice
• 刊名：Epilepsy & Behavior
• 出版年：2012
• 期刊代码：76_15255050
• 类别：neu
• 出版时间：April, 2012
• 卷：23
• 期：4
• 页码：399-404
• 文件大小：522 K

摘要

Atorvastatin has neuroprotective effects, and there is some evidence that nitric oxide is involved in atorvastatin effects. In this study, we evaluated whether the nitrergic system is involved in the anticonvulsant effects of chronic atorvastatin administration. Intravenous and intraperitoneal pentylenetetrazol were used to induce seizures in mice. Chronic atorvastatin treatment significantly increased the seizure threshold which is induced by both intravenous and intraperitoneal pentylenetetrazol. Intraperitoneal pentylenetetrazol also decreased the incidence of tonic seizure and death in atorvastatin-treated groups. Chronic co-administration of a non-selective nitric oxide synthase inhibitor, l-NAME, or a selective inducible nitric oxide synthase inhibitor, aminoguanidine, with atorvastatin inhibited atorvastatin-induced anticonvulsant effects in intravenous model of pentylenetetrazol. Acute injection of l-NAME or aminoguanidine inhibited the anticonvulsant effects of atorvastatin in both models of intravenous- and intraperitoneal-pentylenetetrazol-induced seizures. In conclusion, we demonstrated that nitric oxide signaling probably through inducible nitric oxide synthase could be involved in the anticonvulsant effects of atorvastatin.