Anticonvulsant effect of Marsilea quadrifolia Linn. on pentylenetetrazole induced seizure: A behavioral and EEG study in rats

详细信息	查看全文 | 推荐本文 |

• 作者：Surajit Sahu^a ; ^c ; Goutam Dutta^a ; ^b ; Nilotpal Mandal^a ; Ananda Raj Goswami^a ; ^b ; Tusharkanti Ghosh^a ; ^b ; ^{tushar_physiol2009@yahoo.in}
• 关键词：PTZ ; pentylenetetrazole ; MQ ; Marsilea quadrifolia Linn. ; MM ; Marsilea minuta Linn. ; MR ; Marsilea rajasthansis Gupta ; MQ EE ; Marsilea quadrifolia ethanol extract ; MQ WE ; Marsilea quadrifolia water extract ; EEG ; electroencephalogram ; FFT ; fast Fourier trans
• 刊名：Journal of Ethnopharmacology
• 出版年：2012
• 期刊代码：26_03788741
• 类别：pha
• 出版时间：7 May, 2012
• 卷：141
• 期：1
• 页码：537-541
• 文件大小：422 K

摘要

Ethnopharmacological relevance

Marsilea quadrifolia Linn (MQ) extract has been used traditionally as sedative and antiepileptic drug in India.

Aim of this study

To investigate the anticonvulsive potential of MQ extracts by using behavior and electroencephalographic (EEG) analysis on pentylenetetrazole (PTZ) induced seizure model in rats.

Materials and methods

For anticonvulsant effect, 60 minutes after administration of MQ, behavior and EEG were analyzed during PTZ (60 mg/kg) induced seizures. Changes of EEG power, latency of onset of seizure, seizure severity score, and duration of epileptic seizure were determined.

Results

Both the water and ethanol extract of MQ increased the latency of seizure but also decreased duration of epileptic seizure and seizure severity score. This reduction of seizure severity was also observed in EEG recording and EEG power analysis. The effectiveness of MQ ethanol extract is better than MQ water extract.

Conclusion

Both water and ethanol extract of MQ were effective in reducing the severity of behavioral and EEG seizures induced by PTZ in rats. This study justifies the traditional use of this plant in epilepsy.