Antihyperglycemic and antidyslipidemic agent from Aegle marmelos
- 作者：T. Narender ; S. Shweta ; P. Tiwari ; K. Papi Reddy ; T. Khaliq ; P. Prathipati ; A. Puri ; A.K. Srivastava ; R. Ch ; er ; S.C. Agarwal ; et al.
- 关键词：Aegeline ; Aegle marmelos ; Antihyperglycemic activity ; Antidyslipidemic activity ; β ; 3-AR agonist activity
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2007
- 期刊代码：10_0960894x
- 类别：ch
- 出版时间：15 March 2007
- 卷：17
- 期：6
- 页码：1808-1811
- 文件大小：216 K
摘要
The plant Aegle marmelos belongs to the family of Rutaceae. From the leaves of A. marmelos an alkaloidal-amide, Aegeline 2, was isolated and found to have antihyperglycemic activity as evidenced by lowering the blood glucose levels by 12.9%and 16.9%at 5 and 24 h, respectively, in sucrose challenged streptozotocin induced diabetic rats (STZ-S) model at the dose of 100 mg/kg body weight. Aegeline 2 has also significantly decreased the plasma triglyceride (Tg) levels by 55%(P < 0.001), total cholesterol (TC) by 24%(P < 0.05), and free fatty acids (FFA) by 24%, accompanied with increase in HDL-C by 28%and HDL-C/TC ratio by 66%in dyslipidemic hamster model at the dose of 50 mg/kg body weight. The reasonable mapping of compound 2 to validated pharmacophoric hypothesis and 3D QSAR model with an estimated activity (283 nM) suggest that the compound 2 might be a β3-AR agonist.