Efficacy of six frog skin-derived antimicrobial peptides against colistin-resistant strains of the Acinetobacter baumannii group

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• 作者：J. Michael Conlon^a ; ^{jmconlon@uaeu.ac.ae} ; Agnes Sonnevend^b ; Tibor Pá ; l^b ; Xavier Vila-Farré ; s^c
• 关键词：Frog skin ; Antimicrobial peptide ; Acinetobacter baumannii ; Colistin resistance
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2012
• 期刊代码：126_09248579
• 类别：med
• 出版时间：April, 2012
• 卷：39
• 期：4
• 页码：317-320
• 文件大小：174 K

摘要

The emergence of Acinetobacter sp. strains resistant to all antibacterial agents including colistin necessitates the development of new types of antimicrobial agents. Six cationic 伪-helical frog skin-derived peptides (CPF-AM1, PGLa-AM1, B2RP-ERa, [E4K]alyteserin-1c, [D4K]B2RP and [G4K]XT-7) were selected for this study on the basis of potent growth-inhibitory activity against Gram-negative bacteria and low haemolytic activity against human erythrocytes. All peptides were active against a range of colistin-susceptible [minimum inhibitory concentration (MIC) 鈮?#xA0;2 渭g/mL] and colistin-resistant (MIC 鈮?#xA0;64 渭g/mL) clinical isolates of multidrug-resistant strains of Acinetobacter baumannii and Acinetobacter nosocomialis. The most potent peptides against the colistin-resistant strains were [D4K]B2RP and [E4K]alyteserin-1c (MIC = 4-16 渭g/mL for both). The MIC values of these peptides against the colistin-susceptible strains were in the same range. The frog peptides show potential for development into drugs to treat infections caused by pandrug-resistant Gram-negative pathogens.