Anti-β₂-glycoprotein I antibodies and the antiphospholipid syndrome

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• 作者：Li ; Zhe ; Krilis ; Steven A.
• 关键词：Antiphospholipid syndrome ; Anti-cardiolipin antibodies ; Anti-phospholipid antibodies ; β ; ₂-Glycoprotein I ; Anti β ; ₂-glycoprotein I antibody
• 刊名：Autoimmunity Reviews
• 出版年：2003
• 期刊代码：30_15689972
• 类别：med
• 出版时间：September, 2003
• 卷：2
• 期：5
• 页码：229-234
• 文件大小：91.1 K

摘要

The mechanism of antiphospholipid syndrome (APS) development is still not completely understood. Accumulating evidence indicates that β₂-glycoprotein I (β₂GPI), is the major target antigen for antiphospholipid (aPL) antibodies, which play a crucial role in the pathogenesis of this autoimmune condition. Knowledge about the molecular structure, biological characteristics and function of β₂GPI has been expanding in recent years. In this review, we have focused on some recent important findings on β₂GPI and anti-β₂GPI antibodies in patients and animal models with APS.