Salvage therapy with lenalidomide and dexamethasone in relapsed primary plasma cell leukemia
- 作者：Pellegrino Musto ; Giuseppe Pietrantuono ; Roberto Guariglia ; Oreste Villani ; Maria Carmen Martorelli ; Fiorella D’ ; Auria ; Antonia Zonno ; Rosa Lerose
- 关键词：Atrial natriuretic peptide (ANP) ; Ca2+ efflux ; cGMP compartmentation ; cGMP-dependent protein kinase (cGK) ; Plasma membrane Ca2+-ATPase (PMCA) ; Protein kinase G (PKG) ; Hepatocytes
- 刊名：Leukemia Research
- 出版年：2008
- 期刊代码：186_01452126
- 类别：med
- 出版时间：October 2008
- 卷：32
- 期：10
- 页码：1637-1638
- 文件大小：69 K
摘要
In rat hepatocytes, atrial natriuretic peptide (ANP) elevates cGMP through activation of particulate guanylyl cyclase and attenuates Ca2+ signals by stimulating net plasma membrane Ca2+ efflux. We show here that ANP-stimulated hepatocyte Ca2+ efflux is mediated by protein kinase G (PKG) isotype I. Furthermore, we show that ANP recruits endogenous PKGI
, but not PKGIβ, to the plasma membrane. These effects are mimicked by 8-bromo-cGMP, but not by the soluble guanylyl cyclase activators, sodium nitroprusside and YC-1. We propose that ANP, through localized cGMP elevation, promotes plasma membrane recruitment of PKGI, which, in turn, stimulates Ca2+ efflux.
, but not PKGIβ, to the plasma membrane. These effects are mimicked by 8-bromo-cGMP, but not by the soluble guanylyl cyclase activators, sodium nitroprusside and YC-1. We propose that ANP, through localized cGMP elevation, promotes plasma membrane recruitment of PKGI, which, in turn, stimulates Ca2+ efflux.