Allele 4 of APOE is a stronger predictor of Alzheimer risk in Sicily than in continental South Italy
- 作者：Paolo Bosco ; Rosa-Maria Gué ; ant-Rodrí ; guez ; Guido Anello ; Rosario S. Spada ; Antonino Romano ; Filippo Caraci ; Raffaele Ferri and Jean-Louis Gué ; ant
- 刊名：Neuroscience Letters
- 出版年：2005
- 期刊代码：52_03043940
- 类别：neu
- 出版时间：2005
- 卷：388
- 期：3
- 页码：168-172
- 文件大小：162 K
摘要
The genotype of apolipoprotein E was examined in 173 sporadic Alzheimer's disease (AD) patients, 132 with late onset (LOAD) and 41 with early onset (EOAD), and in 174 healthy matched controls from Sicily. Despite a low frequency of the 4 allele (6.3%, 95%CI: 4.2–9.4) in controls, 4 allele was a stronger predictor of AD risk (odds ratio: 5.8, 95%CI: 3.5–9.4; p < 0.0001) than in most of the studies performed in other regions of Italy, and it has no influence on age at onset. 4/4 and 4/3 genotypes were similar predictors of AD risk. Conversely, a decreased risk was found in 3 allele carriers (odds ratio: 0.3, 95%CI: 0.2–0.4; p < 0.0001), which remained significant when considering EOAD cases only (odds ratio: 0.2, 95%CI: 0.1–0.4, p < 0.0001). In conclusion, differences in association strength of 4 allele with AD between Sicily and other regions of Italy suggest an influence of complex gene–gene and gene–environment interactions.