Effects of aminaftone 75 mg TID on soluble adhesion molecules: A 12-week, randomized, open-label pilot study in patients with systemic sclerosis
- 作者：Raffaella Scorza ; Aless ; ro Santaniello ; Giulia Salazar ; Stefania Lenna ; Silvia Della Bella ; Rita Antonioli ; Karen Toussoun ; Lorenzo Beretta
- 关键词：systemic sclerosis ; adhesion molecules ; aminaftone ; Raynaud's phenomenon
- 刊名：Clinical Therapeutics
- 出版年：2008
- 期刊代码：65_01492918
- 类别：med
- 出版时间：May 2008
- 卷：30
- 期：5
- 页码：924-929
- 文件大小：155 K
摘要
Background: Vasculopathy is one of the hallmarks of systemic sclerosis (SSc), characterized by endothelial activation and over expression of adhesion molecules. A preliminary in vitro study has suggested that aminaftone, a naphtohydrochinone used in the treatment of capillary disorders, may downregulate the expression of adhesion molecules in endothelial cells.