Novel one pot synthesis of polysubstituted pyrazolo[1,5-a]- and imidazo[1,2-a]pyrimidines

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• 作者：Alexander S. Kiselyov and Leon Smith II
• 关键词：One-pot reactions ; Pyrazolo&#x5b ; 1 ; 5-a&#x5d ; pyrimidines ; Imidazo&#x5b ; 1 ; 2-a&#x5d ; pyrimidines ; α ; β ; -Unsaturated imines ; Condensations
• 刊名：Tetrahedron Letters
• 出版年：2006
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：10 April 2006
• 卷：47
• 期：15
• 页码：2611-2614
• 文件大小：110 K

摘要

We have described a convenient regioselective one-pot approach to pyrazolo[1,5-a]- and imidazo[1,2-a]pyrimidine derivatives from α,β-unsaturated imines generated in situ and amino heterocycles. Reaction is general with respect to all three components, namely (i) nitrile, (ii) aldehyde, and (iii) amino heterocycle reagents. Good yields (52–77%), convenient isolation of the targeted molecules are the distinct characteristics of the developed protocol.