Spectroscopic, kinetic and cytotoxic in vitro study of hexafluoroglutarate platinum(II) complex with 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine

详细信息	查看全文 | 推荐本文 |

• 作者：Iwona 艁akomska^a ; ^{dziubek@umk.pl} ; ^{dziubek@cc.uni.torun.pl} ; Kamil Hoffmann^a ; Adrian Topolski^a ; Tomasz Kloskowski^b ; Tomasz Drewa^b
• 关键词：Platinum(II) complex ; Dicarboxylate ; Triazolopyrimidine ; Hydrolysis ; Cytotoxicity in vitro
• 刊名：Inorganica Chimica Acta
• 出版年：2012
• 期刊代码：40_00201693
• 类别：ch
• 出版时间：30 May, 2012
• 卷：387
• 期：Complete
• 页码：455-459
• 文件大小：547 K

摘要

Reaction of cis-[PtI₂(dmtp)₂] (where dmtp - 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine) with silver hexafluoroglutarate [Ag₂(C₅F₆O₄)] yielded new complex [Pt(C₅F₆O₄)(dmtp)₂]路2H₂O. The platinum(II) complex has been characterized by ¹H, ¹⁹F NMR and IR. In additional, kinetics of its hydrolysis and antiproliferative activity in vitro against three cell lines (A549 human non small cell lung carcinoma; A375.S2 human melanoma and mouse B16 melanoma tumors) has been studied.