l-Proline catalyzed efficient one-pot three-component aza-Diels-Alder reactions on nitrostyrylisoxazoles: a facile synthesis of new isoxazolyl tetrahydroquinolines and isoxazolo[2,3-a]pyrimidines
- 作者：E. Rajanarendar ; eligeti_rajan@yahoo.co.in ; M. Nagi Reddy ; K. Govardhan Reddy ; S. Rama Krishna
- 关键词：l-Proline ; Aza-Diels&ndash ; Alder reaction ; Nitrostyrylisoxazoles ; Isoxazolyl tetrahydroquinolines ; Isoxazolo[2 ; 3-a]pyrimidines
- 刊名：Tetrahedron Letters
- 出版年：2012
- 期刊代码：109_00404039
- 类别：ch
- 出版时间：6 June, 2012
- 卷：53
- 期：23
- 页码：2909-2913
- 文件大小：242 K
摘要
l-Proline acts as an efficient organocatalyst and found to promote one-pot three-component aza-Diels-Alder reaction of aryl or isoxazole imines formed in situ from aromatic or isoxazoleamines and aromatic aldehydes with nitrostyrylisoxazoles to afford the isoxazolyl tetrahydroquinolines or isoxazolo[2,3-a]pyrimidines, respectively, in excellent yields at ambient temperature under neutral conditions.