Platinum(II) complexes with 5,7-disubstituted-1,2,4-triazolo [1,5-a]pyrimidines: Spectroscopical characterization and cytotoxic activity in vitro

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• 作者：Iwona 艁akomska^a ; ^{dziubek@cc.uni.torun.pl} ; ^{dziubek@umk.pl} ; Marzena Fandzloch^a ; Beata Pop艂awska^a ; Jerzy Sitkowski^b
• 关键词：Platinum complexes ; Triazolopyrimidines ; 15N NMR ; 195Pt NMR ; X-ray ; Cytotoxic activity
• 刊名：Spectrochimica Acta Part A ; Molecular and Biomolecular Spectroscopy
• 出版年：2012
• 期刊代码：99_13861425
• 类别：ch
• 出版时间：June, 2012
• 卷：91
• 期：Complete
• 页码：126-129
• 文件大小：250 K

摘要

Complexes of the types: cis-[PtI₂(dptp)₂] (1), cis-[PtI₂(NH₃)(dptp)] (2), trans-[PtI₂(dptp)(dmso)] (3) and trans-[PtI₂(dbtp)(dmso)] (4), where dptp = 5,7-diphenyl-1,2,4-triazolo[1,5-a]pyrimidine (dptp), dbtp = 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine have been synthesized and characterized by infrared and multinuclear magnetic resonance spectroscopic techniques (¹H, ¹³C, ¹⁵N, ¹⁹⁵Pt). In ¹⁹⁵Pt NMR, the cis-diiodo complexes were observed between -2601 ppm and -3261 ppm, while the trans coordination compounds were found at higher field (ca. 鈭?389 ppm). In all cases significant ¹⁵N NMR shielding (92-95 ppm) were observed for N(3) atom indicating this nitrogen atom as a coordination site. The cis complexes have been assayed for antitumor activity in vitro against two human cell lines: A549 (non-small cell lung carcinoma) and T47D (breast cancer). The results indicate a moderate antiproliferative activity of (2) against human cancer lines.