Synthesis and biological evaluation of some new substituted benzoxazepine and benzothiazepine as antipsychotic as well as anticonvulsant agents

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• 作者：Hemlata Kaur¹ ; Sunil Kumar ; Archana Chaudhary ; Ashok Kumar ; ^{kashokraj@gmail.com}
• 关键词：Oxa/thiadiazolylbenzoxa/thiazepines ; Azetidinonyl/thiazolidinonylbenzoxa/thiazepines ; Antipsychotic activity ; Anticonvulsant activity ; Acute toxicity
• 刊名：Arabian Journal of Chemistry
• 出版年：2012
• 期刊代码：P35_18785352
• 类别：ch
• 出版时间：July, 2012
• 卷：5
• 期：3
• 页码：271-283
• 文件大小：449 K

摘要

Various 2-((2-((5-benzylideneamino)-1,3,4-oxa/thiadiazol-2-yl)methyl)hydrazinyl) methyl)benzo[b][1,4]oxa/thiazepin-4(5H)-ones g class="boldFont">(4a-4l)g>, 2-((2-((5-(4-oxo-2-substitutedphenyl thiazolidin-3-yl)-1,3,4-oxa/thiadiazol-2-yl)methyl)hydrazinyl)methyl)benzo [b] [1,4]oxa/thiazepin-4(5H)-ones g class="boldFont">(5a-5l)g> and 2-((2-((5-(3-chloro-2-(substitutedphenyl)-4-oxoazetidin-1-yl)-1,3,4-oxa/thia diazol-2-yl)methyl)hydrazinyl)methyl)benzo[b][1,4]oxa/thiazepin-4(5H)-ones g class="boldFont">(6a-6l)g> have been synthesized. The structures of these compounds have been established by elemental (C, H, N) and spectral (IR, ¹H-NMR and Mass) analysis. The synthesized compounds were screened for their antipsychotic and anticonvulsant activities. Compound g class="boldFont">5lg> was found to be the most active compound of this series.