Quantitative imaging of arsenic and its species in goat following long term oral exposure

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• 作者：Pabitra Hriday Patra^a ; Samiran Bandyopadhyay^b ; Rakesh Kumar^a ; Bakul Kumar Datta^a ; Chinmoy Maji^c ; Suman Biswas^c ; Jeevan Ranjan Dash^a ; Tapas Kumar Sar^a ; Samar Sarkar^c ; Sanjib K. Manna^d ; Animesh Kumar Chakraborty^a ; Tapan Kumar Mandal^a ; ^{pharma.tkm@gmail.com}
• 关键词：Sodium arsenite ; Arsenic species ; Hepatotoxicity ; Goat
• 刊名：Food and Chemical Toxicology
• 出版年：2012
• 期刊代码：20_02786915
• 类别：pha
• 出版时间：June, 2012
• 卷：50
• 期：6
• 页码：1946-1950
• 文件大小：415 K

摘要

Severity of arsenic toxicity was reported to vary depending on its species. The present study reflects the status of different species of arsenic in goat following long-term exposure of arsenic leading to hepatic damage. The experiment was conducted with six black Bengal goats, which were administered with sodium arsenite orally at a dose rate of 2 mg kg^鈭? daily for 84 days. Faeces, urine, hair and blood samples were collected from those animals at 14 days interval. Excretion of total arsenic was reduced from 56 days onwards through both faeces and urine indicating higher accumulation of arsenic in body. The speciation study revealed that urinary arsenic was mainly of organic type, whereas hair accumulated almost equal proportion of arsenite, arsenate and organo arsenicals. Goats excreted high proportion of organo arsenicals through faeces possibly due to hepatobiliary secretion of organo arsenic into the gut. Significantly elevated serum alanine aminotransferase and aspartate aminotransferase activities (p < 0.05) alongwith histopathological changes in liver indicated hepatotoxicity. The arsenite fraction increased and organic proportion decreased in urine as the time progressed, which indicates that arsenite gets methylated in liver of goat. The study thus alluded that the toxicity of arsenic would aggravate if the animals were exposed for long time as the hepatotoxicity progressed resulting in decreased methylation and formation of organo arsenicals and decreased excretions through urine.