Major and minor arsenic compounds accounting for the total urinary excretion of arsenic following intake of blue mussels (Mytilus edulis): A controlled human study

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• 作者：M. Molin^a ; ^b ; ^{Marianne.Molin@hioa.no} ; T.A. Ydersbond^c ; ^{Trond.Arild.Ydersbond@ssb.no} ; S.M. Ulven^a ; ^{StineMarie.Ulven@hioa.no} ; M. Holck^a ; ^{Marianne.Holck@hioa.no} ; L. Dahl^d ; ^{Lisbeth.Dahl@nifes.no} ; J.J. Sloth^d ; ^e ; D. Fliegel^d ; ^{Daniel.Fliegel@nifes.no} ; W. Goessler^f ; ^{walter.goessler@uni-graz.at} ; J. Alexander^g ; ^{Jan.Alexander@fhi.no} ; H.M. Meltzer^g ; ^{Helle.Margrete.Meltzer@fhi.no}
• 关键词：AB ; arsenobetaine ; AC ; arsenocholine ; As (III) ; arsenite ; As (V) ; arsenate ; As ; arsenic ; CRM ; certified reference material ; CRP ; C-reactive protein ; DMA ; dimethylarsinate ; DMAB ; dimethylarsenobutanate ; HPLC ; high performance liquid chromatography ; iAs ; in
• 刊名：Food and Chemical Toxicology
• 出版年：2012
• 期刊代码：20_02786915
• 类别：pha
• 出版时间：July, 2012
• 卷：50
• 期：7
• 页码：2462-2472
• 文件大小：547 K

摘要

Blue mussels (Mytilus edulis) accumulate and biotransform arsenic (As) to a larger variety of arsenicals than most seafood. Eight volunteers ingested a test meal consisting of 150 g blue mussel (680 渭g As), followed by 72 h with an identical, low As controlled diet and full urine sampling. We provide a complete speciation, with individual patterns, of urinary As excretion. Total As (tAs) urinary excretion was 328 卤 47 渭g, whereof arsenobetaine (AB) and dimethylarsinate (DMA) accounted for 66%and 21%, respectively. Fifteen minor urinary arsenicals were quantified with inductively coupled plasma mass spectrometry (ICPMS) coupled to reverse-phase, anion and cation-exchange high performance liquid chromatography (HPLC). Thio-arsenicals and non-thio minor arsenicals (including inorganic As (iAs) and methylarsonate (MA)) contributed 10%and 7%of the total sum of species excretion, respectively, but there were large individual differences in the excretion patterns. Apparently, formation of thio-arsenicals was negatively correlated to AB formation and excretion, possibly indicating a metabolic interrelationship. The results may be of toxicological relevance since DMA and MA have been classified as possibly carcinogenic, and six of the excreted As species were thio-arsenicals which recently have been recognized as toxic, while iAs toxicity is well known.