• 作者：Á ; ngel Brea^a ; ^{abrea@riojasalud.es} ; Daniel Mosquera^a ; José ; Marí ; a Mostaza^b ; José ; Luis Aranda^c ; Jorge Argimó ; n^d ; Carmen Sanclemente^e ; Rocí ; o Mateo-Gallego^f ; Fá ; tima Almagro^g ; Nuria Plana^h ; Carlos Recarteⁱ ; Grupo de Unidades de Lí ; pidos del Registro de Hipertrigliceridemias de la Sociedad Españ ; ola de Arteriosclerosis
• 关键词：Hipertrigliceridemia ; Enfermedad del hí ; gado graso no alcohó ; lico ; Riesgo cardiovascular ; Triglicé ; ridos ; Obesidad ; Sí ; ndrome metabó ; lico
• 刊名：Cl铆nica e Investigaci贸n en Arteriosclerosis
• 出版年：2011
• 期刊代码：pca88_02149168
• 类别：med
• 出版时间：March-April 2011
• 卷：23
• 期：2
• 页码：72-77
• 文件大小：171 K

Objectives

Nonalcoholic fatty liver disease (NAFLD) has been associated with both hypertriglyceridemia and an increased risk of cardiovascular complications. The aim of our study was to assess factors related to the presence of NAFLD in patients with hypertriglyceridemia and to calculate their Framingham score risk.

Patients and methods

A total of 1.394 subjects (mean age 50.3 卤 12.4 years, 74.1%male) participating in the Hypertriglyceridemia Register of the Spanish Society of Arteriosclerosis were studied. Hypertriglyceridemia was considered as a triglyceride concentration 鈮?00 mg/dL confirmed on two different occasions. Liver steatosis was diagnosed by ultrasound. NAFLD was defined as the presence of steatosis in patients who were moderate alcohol consumers or abstainers.

Results

Of the 649 subjects included in the final sample, 321 (49.5%) had NAFLD. As expected, liver enzymes were higher in this population. The presence of NAFLD was associated with a higher body mass index (p < 0.001), increased waist circumference (p < 0.001) and a higher prevalence of metabolic syndrome (p < 0.001). No differences in triglyceride concentration or in the prevalence of diabetes were found between subjects with and without NAFLD. A Framingham risk score above 20%was observed in 52.4%of the participants, with no differences in relation to NAFLD status.

Conclusions

Hypertriglyceridemic subjects with NAFLD have a higher prevalence of obesity, mainly abdominal, and metabolic syndrome. The estimated cardiovascular risk in this population is very high but does not differ according to the presence of NAFLD.