- 作者：Walter Masson ; walter.masson@hospitalitaliano.org.ar ; Daniel Siniawski ; Juan Krauss ; Arturo Cagide
- 关键词：Prevenció ; n primaria ; Ecuaciones de riesgo cardiovascular ; Arterias caró ; tidas ; Placa de ateroma
- 刊名：Revista Espa帽ola de Cardiolog铆a
- 出版年：2011
- 期刊代码：pca308_03008932
- 类别：med
- 出版时间：April 2011
- 卷：64
- 期：4
- 页码：305-311
- 文件大小：276 K
Introduction and objectives
The traditional Framingham score underestimates cardiovascular risk in certain populations. Extending its time-scale to 30 years and assessing its relationship with the presence of carotid atherosclerotic plaque may improve risk stratification. The objectives were: a) to determine the percentage of patients previously classified with the traditional score who were reclassified when using Framingham 30-year risk score; b) to analyze the prevalence of carotid atherosclerotic plaque; and c) to determine the diagnostic potential of the 30-year score to detect carotid plaque.
Methods
A carotid Doppler ultrasound study was performed and the Framingham 10-year risk score and 30-year score (based on lipids and body mass index) for 鈥渉ard鈥?cardiovascular events were calculated in a population of primary prevention patients. Prevalence of carotid plaque was determined. Receiver operating characteristic analysis was conducted.
Results
In total, 305 subjects were included (age 48 [11] years, 52%men). The 30-year scores based on lipids and on body mass index reclassified 70%and 63%of the population, respectively. Prevalence of carotid plaque was 28.5%and associated gradually with risk category. The area under the curve and optimal cutoff points of the 30-year score to detect carotid plaque were 0.862 and 26%(based on lipids) and 0.845 and 22%(based on body mass index), respectively.
Conclusions
The 30-year score reclassified a large number of patients and discriminated between those with or without evidence of carotid plaque.
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