Design and synthesis of fluorescent 6-aryl[1,2-c]quinazolines serving as selective and sensitive 鈥榦n-off鈥?chemosensor for Hgup>2+up> in aqueous media

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• 作者：Rampal Pandey ; Mahendra Yadav ; Mohammad Shahid ; Arvind Misra ; Daya Shankar Pandeyup> ; up>up>dspbhu@bhu.ac.inup>up> ; up>up>dsprewa@yahoo.comup>
• 关键词：Synthesis ; Quinazolines ; Crystal structure ; UV&ndash ; vis ; Fluorescence ; Mercury selective ; Quenching
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：11 July, 2012
• 卷：53
• 期：28
• 页码：3550-3555
• 文件大小：756 K

摘要

Three fluorescent quinazolines thiophen-2-yl-5,6-dihydrobenzo-[4,5]imidazo[1,2-c]quinazoline (1), pyridin-3-yl-5,6-dihydrobenzo-[4,5]imidazo-[1,2-c]quinazoline (2) and phenyl-5,5鈥?6,6鈥?dihydrobenzo-[4,4鈥?5,5鈥瞉imidazo-[1.1鈥?2-c,2鈥?c]quinazoline (3) have been synthesized. Structures of 1 and 3 have been authenticated crystallographically. Quinazolines 1-3 exhibit highly selective 鈥榦n-off鈥?switching for Hgup>2+up> ions. The fluorescence intensity displayed a linear relationship with respect to Hgup>2+up> concentration (0.1-1.0 渭M; Rup>2up> = 0.99) with detection limit of 2.0 脳 10up>鈭?up> M.