Diagnosis and assessment of apathy in Chinese patients with Alzheimer's disease

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• 作者：Hongyi Zhao^a ; Zhongxin Zhao^a ; Liuqing Huang^a ; ^{huangliuqing2008@hotmail.com} ; Maurice Preter^b ; ^c ; ^d
• 关键词：Alzheimer's Disease ; Apathy ; Assessment tool ; Diagnostic criteria
• 刊名：Journal of Psychosomatic Research
• 出版年：2012
• 期刊代码：170_00223999
• 类别：med
• 出版时间：May, 2012
• 卷：72
• 期：5
• 页码：405-407
• 文件大小：131 K

摘要

Background

Apathy is a major component of the behavioral and psychological symptoms of Alzheimer's Disease (AD) and other types of dementia. Most researchers have reached a consensus on a new set of diagnostic criteria for apathy (DCA) recently. However, no relevant reports on apathy exist for AD patients in Asian countries yet.

Objectives

To estimate the prevalence of apathy in Chinese AD patients.

Methods

83 AD patients were recruited for a cross-sectional observational study. Following the new diagnostic criteria for apathy (DCA) and DSM-IV criteria for Major Depressive Disorder (MDD), each patient was assessed successively by Mini Mental State Examination (MMSE), the Neuropsychiatric Inventory-apathy subscale (NPI-apathy), the Geriatric Depression Screening scale (GDS), and the Caregiver Burden Scale (CBS).

Results

According to the DCA, we found that the frequency of apathy in Chinese AD patients reached 61.4%. The DCA had very good standard validity and internal consistency. The frequency of apathy was not significantly associated with that of depression, whereas there was a significant association between apathy and more severe cognitive deficits. Caregiver burden was significantly associated with severity of apathy.

Conclusions

From the symptoms of a group of Chinese AD patients, we summarized a set of effective methods for the diagnosis and assessment of apathy.