Predicting the risk of lymph node invasion during radical prostatectomy using the European association of urology guideline nomogram: A validation study

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• 作者：J. Schmitges^a ; ^b ; ^{janschmitges@gmx.de} ; P.I. Karakiewicz^b ; M. Sun^b ; F. Abdollah^c ; L. Budä ; us^d ; H. Isbarn^d ; M. Bianchi^c ; Q.-D. Trinh^e ; T. Schlomm^a ; F.K. Chun^d ; M. Graefen^a ; T. Steuber^a
• 关键词：Prostatic neoplasm/pathology ; Lymphatic metastasis/diagnosis ; Lymph node excision/statistics & numerical data ; Pelvis ; Male
• 刊名：European Journal of Surgical Oncology (EJSO)
• 出版年：2012
• 期刊代码：121_07487983
• 类别：med
• 出版时间：July, 2012
• 卷：38
• 期：7
• 页码：624-629
• 文件大小：337 K

摘要

Background

The 2011 European Association of Urology (EAU) guidelines for prostate cancer recommend a pelvic lymph node dissection (PLND) at radical prostatectomy (RP) in all individuals with a nomogram predicted lymph node invasion (LNI) risk of >7%.

Methods

To test the performing characteristics for several thresholds (1-14%) and to examine the overall accuracy and calibration plot of the EAU nomogram at our institution. The study population consisted of 3081 patients treated with RP and PLND limited to the obturator fossa and the external iliac vein between 2008 and 2010 at a single European institution from Germany. More extensive PLNDs were performed at the surgeon鈥檚 discretion.

Results

Overall, 260 patients (9.2%) had LNI. The 7%threshold would have avoided 30%of PLNDs, at the cost of missing 8%of patients with LNI. The use of 8%and 9%threshold would have allowed the avoidance of respectively 39%and 48%of PLNDs, at the cost of missing respectively 12%and 14%of patients with LNI. The accuracy of the LNI nomogram was 78%, and the unadjusted departure from ideal calibration was 5.3%.

Conclusions

We confirmed adequate accuracy and calibration of the LNI nomogram. The 7%cut-off may be overly conservative. Better trade-offs between avoided PLNDs and missed LNI cases may be achieved with a limit of 8 or even 9%.