Patients with schizophrenia (n = 321) were identified systematically after screening 68 378 adults, ages 15-49 years, in rural Ethiopia. The majority (74.9%) had chronic illness at entry and were treatment na茂ve (89.6%).
During 5-year follow-up, 96%had received treatment at least once although only about 6%had received antipsychotic treatments continuously. Forty five percent of participants were continuously symptomatic with 30.3%having had continuous psychotic episode. About 20%had experienced continuous remission. Being single (OR = 3.41, 95%CI = 1.08-10.82, P = 0.037), on antipsychotic treatment for at least 50%of follow up time (OR = 2.28, 95%CI = 1.12-4.62, P = 0.023), and having a diagnosis of paranoid subtype of schizophrenia (OR = 3.68, 95%CI = 1.30-10.44, P = 0.014) were associated with longer period of remission
The findings from this 5-year outcome were consistent with our previous short term report which was unfavorable. Treatment has been a consistent predictor of a favorable outcome. Therefore, ensuring availability of treatment and adherence is an essential pragmatic step to improve outcome in this setting.