MetaPath: An electronic knowledge base for collating, exchanging and analyzing case studies of xenobiotic metabolism

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• 作者：Richard C. Kolanczyk^a ; ^{kolanczyk.rick@epa.gov} ; Patricia Schmieder^a ; William J. Jones^b ; Ovanes G. Mekenyan^c ; Atanas Chapkanov^c ; Stanislav Temelkov^c ; Stefan Kotov^c ; Maria Velikova^c ; Verginia Kamenska^c ; Krasimir Vasilev^c ; Gilman D. Veith^d
• 关键词：Metabolism ; Database ; Metabolic maps ; Biotransformation ; MetaPath ; Pathways ; DER Composer ; Risk assessment
• 刊名：Regulatory Toxicology and Pharmacology
• 出版年：2012
• 期刊代码：57_02732300
• 类别：pha
• 出版时间：June, 2012
• 卷：63
• 期：1
• 页码：84-96
• 文件大小：3526 K

摘要

The MetaPath knowledge base was developed for the purpose of archiving, sharing and analyzing experimental data on metabolism, metabolic pathways and crucial supporting metadata. The MetaPath system grew out of the need to compile and organize the results of metabolism studies into a systematic database to facilitate data comparisons and evaluations. Specialized MetaPath data evaluation tools facilitate the review of pesticide metabolism data submitted for regulatory risk assessments as well as exchange of results of complex analyses used in regulation and research. Customized screen editors called Composers were developed to automate data entry into MetaPath while also streamlining the production of agency specific study summaries such as the Data Evaluation Records (DER) used by the US EPA Office of Pesticide Programs. Efforts are underway through an Organization for Economic Co-operation and Development (OECD) work group to extend the use of DER Composers as harmonized templates for rat metabolism, livestock residue, plant residue and environmental degradation studies.