Risk Stratification Assessed by Combined Lung and Heart Iodine-123 Metaiodobenzylguanidine Uptake in Patients With Idiopathic Dilated Cardiomyopathy
- 作者：Yuichi Kamiyoshi ; Yoshikazu Yazaki ; Kazutoshi Urushibata ; Tomonori Koizumu ; Hiroki Kasai ; Atsushi Izawa ; Osamu Kinoshita ; Minoru Hongo ; Uichi Ikeda
- 关键词：Glycosidase inhibitors ; Spiro compounds ; Imidazoline ; Carbocyclic compounds
- 刊名：The American Journal of Cardiology
- 出版年：2008
- 期刊代码：5_00029149
- 类别：med
- 出版时间：15 May 2008
- 卷：101
- 期：10
- 页码：1482-1486
- 文件大小：355 K
摘要
A new scaffold consisting of a carbocycle and a substituted imidazoline in an orthogonal arrangement was synthesized as a potential specific inhibitor of glycosidases. The spirobicycloimidazoline, (5R,6R,7R,8R)-8-(hydroxymethyl)-2-phenyl-1,3-diazaspiro[4.4]non-1-ene-6,7-diol, was synthesized from methyl 2-O-p-methoxybenzyl-3,4-di-O-benzyl-
/β-d-gluco-6-enopyranoside via (1R,2S,3S,4R,5S)-3,4-bis(benzyloxy)-2-(4-methoxybenzyloxy)-5-vinyl-cyclopentanol. The ring contraction of the 6-enopyranoside in the presence of zirconocene equivalent (‘Cp2Zr’) reagent gave exclusively the corresponding cyclopentanol without cleavage of the PMB protecting group. In the course of the study, a new -mannosidase inhibitor, (1R,2R,3R,5R)-5-amino-3-hydroxymethyl-cyclopentane-1,2-diol, was also discovered.
/β-d-gluco-6-enopyranoside via (1R,2S,3S,4R,5S)-3,4-bis(benzyloxy)-2-(4-methoxybenzyloxy)-5-vinyl-cyclopentanol. The ring contraction of the 6-enopyranoside in the presence of zirconocene equivalent (‘Cp2Zr’) reagent gave exclusively the corresponding cyclopentanol without cleavage of the PMB protecting group. In the course of the study, a new -mannosidase inhibitor, (1R,2R,3R,5R)-5-amino-3-hydroxymethyl-cyclopentane-1,2-diol, was also discovered.