A double-blind, randomized controlled trial of the use of a 50:50 mixture of nitrous oxide/oxygen in legal abortions

详细信息	查看全文 | 推荐本文 |

• 作者：Aubert Agostini ; ^{aubert.agostini@ap-hm.fr} ; Julia Maruani ; Pascale Roblin ; Jocelyne Champion ; Ludovic Cravello ; Marc Gamerre
• 关键词：Nitrous oxide ; Surgical abortion ; Pain
• 刊名：Contraception
• 出版年：2012
• 期刊代码：71_00107824
• 类别：med
• 出版时间：July, 2012
• 卷：86
• 期：1
• 页码：79-83
• 文件大小：124 K

摘要

Background

The study was conducted to evaluate the effectiveness of oxygen/nitrous oxide (O₂/N₂O) in elective abortions by vacuum aspiration with paracervical block and intravenous paracetamol.

Design

This single-center double-blinded randomized study tested O₂/N₂O (n=36) and placebo (air, n=36) for additional analgesia in elective abortions with paracervical block and intravenous paracetamol. We assessed intra- and postoperative pain according to both a visual analogic scale rated from 0 to 10 and postoperative analgesic requirements.

Results

Mean (卤SD) intraoperative, immediate postoperative and late postoperative pain did not differ significantly for patients with O₂/N₂O and with air [3.4卤2.6 vs. 3.7卤3.05 (p=.75), 1.89卤2.4 vs. 1.56卤2.03 (p=.78), 0.5卤0.8 vs. 0.75卤1.2 (p=.45)]. The number of patients with scores for low (0-4), moderate (4-7) and severe (7-10) intraoperative, immediate postoperative and late postoperative pain did not differ significantly between the groups. Total adverse effects were significantly higher in the O₂/N₂O group [35/180 (19.4%) vs. 18/180 (10%), p=.01].

Conclusion

O₂/N₂O did not reduce intraoperative or postoperative pain in elective abortions by vacuum aspiration with paracervical analgesia and intravenous paracetamol, and its adverse effect rate was substantial.