Baroreflex modulation during sleep and in obstructive sleep apnea syndrome

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• 作者：P. Cortelli^a ; C. Lombardi^c ; ^d ; P. Montagna^b ; ¹ ; G. Parati^c ; ^d ; ^{gianfranco.parati@unimib.it}
• 关键词：ANS ; autonomic nervous system ; OSA (OSAS) ; obstructive sleep apnea (syndrome) ; AH ; arterial hypertension ; EDS ; excessive daytime sleepiness ; NTS ; nucleus of the solitary tract ; CVLM ; caudal ventrolateral medulla ; NA ; nucleus ambiguus ; SON ; supraoptic nucl
• 刊名：Autonomic Neuroscience
• 出版年：2012
• 期刊代码：31_15660702
• 类别：med
• 出版时间：2 July, 2012
• 卷：169
• 期：1
• 页码：7-11
• 文件大小：173 K

摘要

This review focuses on the complex integration between cardiovascular reflexes and central autonomic influences controlling physiological sleep-dependent changes in arterial blood pressure and heart rate. A brief introduction on the anatomic and functional organization of the arterial baroreflex and the methods available to assess its function in humans is followed by an analysis of the functional interaction between autonomic nervous system and sleep mechanisms at the highest levels of brain organization. An insight into these interactions is important to shed light on the physiopathology of the most frequent complications of obstructive sleep apnea syndrome, such as sustained arterial hypertension, and excessive daytime sleepiness.