Palladium-catalyzed cross-couplings of functionalized 2-bromobenzofurans for atom-economic synthesis of 2-arylbenzofurans using triarylbismuth reagents
- 作者：Maddali L.N. Rao ; maddali@iitk.ac.in ; Dheeraj K. Awasthi ; Jalindar B. Talode
- 关键词：2-Bromobenzofuran ; Triarylbismuths ; Palladium catalysis ; Cross-couplings ; Atom-economic
- 刊名：Tetrahedron Letters
- 出版年：2012
- 期刊代码：109_00404039
- 类别：ch
- 出版时间：23 May, 2012
- 卷：53
- 期：21
- 页码：2662-2666
- 文件大小：3884 K
摘要
The palladium catalyzed, atom-economic synthesis of various functionalized 2-arylbenzofurans was achieved through cross-coupling reaction of 2-bromobenzofurans with triarylbismuth reagents. The palladium catalytic protocol is very efficient to furnish various cross-coupled functionalized 2-arylbenzofurnas in high yields using triarylbismuth reagents with three aryl couplings as multi-coupling organometallic nucleophiles in one-pot operation. All the coupling reactions were completed in 1 h short reaction time involving three couplings from triarylbismuths under heating condition.