N-amination of amino acids and its derivatives using N-Boc-O-tosyl hydroxylamine as an efficient NH-Boc transfer reagent: electrophilic amination

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• 作者：Thankappan Baburaj^a ; Sivalingam Thambidurai^b ; ^{sthambi01@yahoo.co.in}
• 关键词：Electrophilic N-amination ; 尾-Boc-hydrazino acids ; 尾-Boc-hydrazino esters ; Modified amino acids ; N-Boc-O-tosyl hydroxylamine ; Azapeptides
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：2 May, 2012
• 卷：53
• 期：18
• 页码：2292-2294
• 文件大小：1966 K

摘要

Terminal tert-butyloxycarbonyl (Boc) protected hydrazino acids, useful intermediates for modified peptides and biologically active heterocyclic derivatives, were synthesized by electrophilic amination methodology using N-Boc-O-tosyl hydroxylamine as an efficient NH-Boc transfer reagent. Also, we have demonstrated the conversion of other amino acid derivatives such as amino esters and amino alcohols into 尾-Boc-hydrazino derivatives using this reagent.