Synthesis and NMR experiments of (4,5,6-¹³C)-deoxymannojirimycin. A new entry to ¹³C-labeled glycosidase inhibitors

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• 作者：Caterina Murruzzu ; Mò ; nica Alonso ; Angeles Canales ; Jesus Jimé ; nez-Barbero ; Antoni Riera
• 关键词：Glycosidase inhibitors ; Azasugars ; Labeled compounds ; Sharpless epoxidation
• 刊名：Carbohydrate Research
• 出版年：2007
• 期刊代码：15_00086215
• 类别：ch
• 出版时间：3 September 2007
• 卷：342
• 期：12-13
• 页码：1805-1812
• 文件大小：371 K

摘要

The synthesis of (4,5,6-¹³C)-deoxymannojirimycin is described. The route employed is based on Sharpless asymmetric epoxidation of (1,2,3-¹³C)(E)-2,4-pentadien-1-ol and uses ring-closing metathesis as a key step. The labeled compound may be easily used for protein-binding experiments using NMR spectroscopic methods.