Antimicrobial activity of the methanolic extracts and compounds from Treculia obovoidea (Moraceae)
- 作者：Victor Kuete ; Robert Metuno ; Bathé ; lé ; my Ngameni ; Armelle Mbaveng Tsafack ; Franç ; ois Ng ; eu ; Ghislain Wabo Fotso ; Merhatibeb Bezabih ; Franç ; ois-Xavier Etoa ; Bonaventure Tchaleu Ngadjui
- 关键词：Treculia obovoidea ; Moraceae ; Compounds ; Antimicrobial activity
- 刊名：Journal of Ethnopharmacology
- 出版年：2007
- 期刊代码：26_03788741
- 类别：pha
- 出版时间：25 July 2007
- 卷：112
- 期：3
- 页码：531-536
- 文件大小：262 K
摘要
The crude extract from Treculia obovoidea was subjected to purification by repeated chromatography. Eight compounds were isolated from Treculia obovoidea and identified as Psoralen (1), Bergapten (2), 7-methoxycoumarin (3), 7-hydroxycoumarin (4), 4,2′,4′-trihydroxychalcone (5), 4,2′,4′-trihydroxy-3-prenylchalcone (6), 3-hydroxy-4-methoxybenzoic acid (7) and O-[3-(2,2-dimethyl-3-oxo-2H-furan-5-yl) butyl] bergaptol (8). These compounds together with the extract were tested for their antimicrobial activity against Gram-positive bacteria (six species), Gram-negative bacteria (12 species) and three Candida species using micro-dilution methods for the determination of the minimal inhibition concentration (MIC) and the minimal microbicidal concentration (MMC). The MIC values obtained with the crude extracts varied from 78.12 to 156.25 μg/ml against 17 (80.95%) of the 21 tested microorganisms. All the isolated compounds showed selective activity. The antimicrobial activity of this plant as well as that of compounds 6 and 8 is being reported for the first time. The obtained results provide promising baseline information for the potential use of these crude extract as well as some of the isolated compounds in the treatment of bacterial and fungal infections.