Beta-catenin expression is prognostic of improved non-small cell lung cancer survival

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• 作者：Connie G. Chiu ; M.D.^a ; Simon K. Chan ; M.Sc.^b ; Z. Amy Fang ; M.D.^c ; Hamid Masoudi ; M.D. ; F.R.C.S.C.^d ; Richard Wood-Baker ; D.M. ; F.R.A.C.P.^e ; ^f ; ^g ; Steven J.M. Jones ; Ph.D.^b ; Blake Gilks ; M.D. ; F.R.C.P.C.^d ; ^f ; Janessa Laskin ; M.D. ; F.R.C.P.C.^e ; Sam M. Wiseman ; M.D. ; F.R.C.S.C.^a ; ^{smwiseman@providencehealth.bc.ca}
• 关键词：Lung cancer ; Beta-catenin ; Tissue microarray ; Non&ndash ; small-cell lung cancer ; Molecular prognosticator
• 刊名：The American Journal of Surgery
• 出版年：2012
• 期刊代码：9_00029610
• 类别：med
• 出版时间：May, 2012
• 卷：203
• 期：5
• 页码：654-659
• 文件大小：214 K

摘要

Introduction

The objectives of this study were to determine the frequency and prognostic significance of beta-catenin expression in a cohort of non-small cell lung cancer (NSCLC) patients.

Methods

Tissue microarrays were constructed using clinically annotated formalin-fixed paraffin-embedded tumor samples from individuals diagnosed with NSCLC who underwent surgical resection with curative intent and had beta-catenin expression status determined by immunohistochemistry.

Results

Negative beta-catenin expression was seen in 28%(103/370) of NSCLC cases and was prognostic of a reduced overall patient survival (P = .008) and also was significantly correlated with the presence of lymphatic invasion (P = .015). In multivariate analysis, the loss of beta-catenin expression retained independent prognostic significance and showed an adjusted hazard ratio of 3.18 (confidence interval, 1.46-6.91, P = .004) for reduced patient survival when adjusting for the presence of lymphatic invasion, tumor grade, nodal status, and tumor stage.

Conclusions

Beta-catenin represents an important prognostic marker in individuals diagnosed with surgically resectable NSCLC.