Choline rise in the rat hippocampus induced by electroconvulsive shock treatment

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• 作者：Sartorius ; Alexander ; Neumann-Haefelin ; Claudia ; Vollmayr ; Barbara ; Hoehn ; Mathias ; Henn ; Fritz A.
• 关键词：Choline increase ; depression ; rat hippocampus ; electroconvulsive shock ; magnetic resonance spectroscopy ; brain
• 刊名：Biological Psychiatry
• 出版年：2003
• 期刊代码：34_00063223
• 类别：med
• 出版时间：April 1, 2003
• 卷：53
• 期：7
• 页码：620-623
• 文件大小：95.5 K

摘要

Human hippocampal choline decreases in major depression episodes. This decrease was recently measured by 1H magnetic resonance spectroscopy (MRS), and it has been found that its level normalizes during antidepressive electroconvulsive therapy. We hypothesized a hippocampal choline increase in the rat brain under electroconvulsive shock (ECS) treatment.